Joanna O. Bryan (b. Leary) (c.1850-?) was born in Ireland and died in an unknown location. She was a dressmaker. She was married to John O'Brien, an engineer, and they lived in Boston, Massachusetts, in the 1870s and 1880s. Bryan studied Christian Science with Josephine C. Woodbury, one of Mary Baker Eddy's students, and applied for the Primary course with Eddy in 1888, but the available records do not indicate that she took it. She joined the Church of Christ (Scientist) in Boston on March 21, 1886, and her daughter Mary E. Bryan joined as well. Mary also performed in the Children's Easter Concert, a Christian Science service held in Chickering Hall, on April 1, 1888. Bryan was listed as a practitioner in The Christian Science Journal in 1887 and 1888. .

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