Mary E. Bryan (b. O'Brien) (1875-?) was born in Hyde Park, Massachusetts, and died in an unknown location. She joined the Church of Christ (Scientist) in Boston, Massachusetts, in the fall of 1886 and performed in the Children's Easter Concert, a Christian Science service held in Chickering Hall, on April 1, 1888. Bryan was the daughter of Joanna O. Bryan (b. Leary) who studied Christian Science with Mary Baker Eddy's student Josephine C. Woodbury, joined the Church of Christ (Scientist) in Boston in March 1886, and was a Christian Science practitioner.

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