Caroline W. Frame (b. Willets) (1841-1925) was born in Bayside, New York, and died in Manhattan, New York. She married Charles P. Frame, who made a fortune in the insurance business in Flushing, New York, in 1861. Frame was originally a student of Laura V. Lathrop's, who was a student of Mary Baker Eddy's. In 1887, Frame helped organize First Church of Christ, Scientist, New York, New York. Frame was a student of Eddy's, completing the Primary class in March 1888 and the Normal class in November 1898. She became a member of the Christian Scientist Association in April 1888, and she was also a member of the National Christian Scientist Association. She was a charter member of Second Church of Christ, Scientist, New York, New York, in 1891. She was one of the First Members of The Mother Church, later known as "Executive Members," who was one of twenty elected to join the original twelve members of the church when it was formed on September 23, 1892. In 1896, she was a charter member of West Side Church of Christ, Scientist, New York, New York (renamed "Fourth Church of Christ, Scientist, New York, New York" in 1901), where she served as First Reader for many years. In 1904, Frame became a member of the General Association of Teachers. Frame was listed in the directory of The Christian Science Journal as a Christian Science practitioner and teacher in New York, New York, from 1892 to 1915.

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